

Pox's unit, dubbed a HoloPox, allows him to communicate with, advise, and vex Crypto down on Earth. Pox has downloaded his consciousness into a personal holographic projector designed to communicate between Furons on Motherships and planet surfaces. Orthropox 13 has died after a Soviet nuclear missile destroyed the Furon mothership. Ten years have gone by since Crypto defeated Majestic and took over the American government. Destroy All Humans! takes place in 1959 Destroy All Humans! 2 takes place in 1969 Destroy All Humans! Big Willy Unleashed takes place in 1975 Destroy All Humans! Path of the Furon takes place in 1979. Destroy All Humans! Path of the Furon is available on Xbox 360 (and PlayStation 3 only in Australia and Europe), and involves Crypto seeking enlightenment to help him stop a conspiracy that threatens the Furon empire. Destroy All Humans! Big Willy Unleashed involves Crypto protecting Pox's new fast food chain using a giant robot mech disguised as the restaurant's mascot, called "Big Willy". Destroy All Humans! 2 features Crypto hunting for revenge, after the KGB try to assassinate him and successfully destroy the mothership and his mission officer, Orthopox, as well as exterminating the Furons' enemy from the Martian War, the Blisk. In Destroy All Humans!, Crypto's objectives also include investigating what happened to his previous clone. The games take place mostly on Earth where the Furon Cryptosporidium, also known as Crypto, is tasked by his superiors to gather Furon DNA locked inside human brain stems in order to save his race from cloning themselves to extinction.
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The musical score for the series is performed by composer Garry Schyman.

Grant Albrecht and Richard Steven Horvitz, with the exception of the game Big Willy Unleashed, in which actors Sean Donnellan and Darryl Kurylo portray the characters. The two main protagonists of the series are voiced by J. A remake of the original game was developed by Black Forest Games and was released in 2020.

Destroy All Humans was ported to Google Stadia. On Ap Destroy All Humans! was added to Xbox’s backwards compatibility program. Destroy All Humans! and Destroy All Humans! 2 were ported to the PlayStation 4 on Octo and Novem both being upscaled to 1080p. Destroy All Humans! is available for the PlayStation 2 and Xbox, Destroy All Humans! 2 is available for the PlayStation 2 and Xbox, Destroy All Humans! Big Willy Unleashed is available for the Wii, and Destroy All Humans! Path of the Furon is available for the Xbox 360 and PlayStation 3 (in Australia and Europe).

PlayStation 2, Xbox, Wii, PlayStation 3, Xbox 360, PlayStation 4, Xbox One, PlayStation 5, Xbox Series X/S, Microsoft Windows, Stadia, Nintendo Switchĭestroy All Humans! is an open world action-adventure video game franchise that is designed as a parody of Cold War-era alien invasion films.
